A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) C07H 21/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2268945
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphils; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.
L'invention concerne de nouveaux amphiphiles cationiques facilitant le transport de molécules (thérapeutiques) biologiquement actives dans des cellules. Selon cette invention, un tel amphiphile cationique est utilisé dans un état dans lequel il est capable d'accepter des protons supplémentaires, c'est-à-dire qu'il n'est pas entièrement saturé en protons. Dans le cadre de cette invention, les amphiphiles cationiques peuvent être regroupés en quatre catégories générales: (A) amphiphiles en T/stéroïdiens; (B) amphiphiles en T/ non stéroïdiens; (C) amphiphiles n'étant pas en T/ stéroïdiens, et (D) amphiphiles n'étant pas en T/ non stéroïdiens.
Chang Chau Dung
Cheng Seng H.
Eastman Simon J.
Harris David J.
Lee Edward R.
Blake Cassels & Graydon Llp
Genzyme Corporation
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