Cd20-binding polypeptide compositions

Details Cd20-binding polypeptide compositions Cd20-binding polypeptide compositions

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2535515

The invention relates to polypeptide compositions that bind to CD20 antigen, especially human CD20 antigen. The polypeptide composistions have the biological activity of known anti-CD20 antibodies, such as 2B8 or Leu16, but show a reduced immunogenicity as compared with the non-~modified molecules. The polypeptide compositions include chimeric antibodies, antibody fragments, and fusion proteins of an antibody or antibody fragment with a cytokine.

Cette invention concerne des compositions de polypeptides qui se lient à l'antigène CD20, en particulier à l'antigène CD20 humain. Ces compositions de polypeptides présentent l'activité biologique d'anticorps anti-CD20 connus, tels que 2B8 ou Leu16 mais offrent une immunogénicité réduite par rapport aux molécules non modifiées. Les compositions de polypeptides de cette invention comprennent des anticorps chimériques, des fragments d'anticorps et des protéines de fusion d'un anticorps ou d'un fragment d'anticorps avec une cytokine.

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