C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01) C12N 5/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2597922
The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP- ribosyl cyclase activity of CD38 and the use of such, compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
La présente invention a trait à des procédés pour la modulation de l'activité migratoire de cellules exprimant le CD38 pour le traitement de troubles comprenant, mais de manière non limitative, l'inflammation, l'ischémie, l'asthme, les maladies auto-immunes, le diabète, l'arthrite, les allergies, l'infection par des organismes pathogènes, tels que des parasites, et le rejet de greffe. De telles cellules comprennent, par exemple, des neutrophiles, des lymphocytes, des polynucléaires éosinophiles, des macrophages et des cellules dendritiques. L'invention a également trait à des dosages de criblage de médicaments destinés à identifier des composés modulateurs de l'activité ADP-rybosyle cyclase de CD38 et l'utilisation de tels composés dans le traitement de troubles impliquant la migration cellulaire modulée par le CD38. L'invention a trait en outre à l'isolement et la caractérisation d'un homologue de CD38 à partir d'un plathelminthe, Schistosoma mansoni.
Lund Frances E.
Partida-Sandchez Santiago
Randall Troy D.
Ridout & Maybee Llp
Trudeau Institute Inc.
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