C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/130, 195/1.2
C12N 15/40 (2006.01) A61K 39/12 (2006.01) C07K 14/12 (2006.01) C07K 14/145 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2035386
ABSTRACT The present invention relates, in general, to a methodology suitable for generating infectious negative-stranded viruses, suitable for use as vaccines, from cloned complementary deoxyribonucleic (cDNA). The invention relates specifically to cDNA molecules and to helper cells suitable as tools in this methodology and to the characterization of the resulting viruses. Measles virus (MV) is used as a model for negative-strand RNA viruses. The described invention provides the technology for construction of recomibnant MV vaccine strains encoding epitopes or entire proteins from heterologous viruses, bacteria, or parasites. With slight modification of the technology described, any negative-stranded RNA virus can by used as vector in place of MV.
Ballart Isidro
Billeter Martin A.
Cattaneo Roberto
Eschle Daniel
Schmid Anita
Ballart Isidro
Billeter Martin A.
Blake Cassels & Graydon Llp
Cattaneo Roberto
Eschle Daniel
LandOfFree
Cdna corresponding to the genome of negative-strand rna... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cdna corresponding to the genome of negative-strand rna..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cdna corresponding to the genome of negative-strand rna... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1492001