Cdna encoding a novel human protein tyrosine phosphatase

Details Cdna encoding a novel human protein tyrosine phosphatase Cdna encoding a novel human protein tyrosine phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12Q 1/42 (2006.01)

Patent

CA 2171610

A novel human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This novel PTP, denoted POTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.

Une nouvelle protéine humaine, la tyrosine-phosphatase (PTP), a été identifiée et l'ADNc qu'elle renferme a été isolé. Cette nouvelle PTP, appelée PTP-OB, a une structure tri-dimensionnelle analogue à celle d'un récepteur, et est présente dans des ostéoblastes. La PTP-OB intervient dans la différenciation des ostéoblastes, et les modulateurs de l'acitivité de la PTP-OB modulent à leur tour la différenciation des ostéoblastes, ainsi que la différenciation et l'activité des ostéoblastes.

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