Cdx2 is downstream mediator of apc tumor suppressor activity

Details Cdx2 is downstream mediator of apc tumor suppressor activity Cdx2 is downstream mediator of apc tumor suppressor activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2372661

Human CDX2, a homeobox gene, has been identified as a downstream effector of tumor suppressor APC. APC induces the transcription of CDX2. This newly found relationship permits specific drug screening assays as well as therapeutic and diagnostic methods.

La présente invention concerne un CDX2 humain, une homéoboîte, ayant été identifié en tant qu'effecteur aval de la suppression des tumeurs de la polypose rétro-colique familiale. La polypose rétro-colique familiale induit la transcription de CDX2. Cette relation nouvellement découverte permet des dosages de criblage des médicaments spécifiques ainsi que des méthodes diagnostiques et thérapeutiques.

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