Cell death related drug targets in yeast and fungi

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07K 14/37 (2006.01) C07K 14/39 (2006.01) C07K 14/395 (2006.01) C07K 14/40 (2006.01) C07K 16/14 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2380875

The invention describes the use of nucleic acids and polypeptides which are involved in a pathway eventually leading to programmed cell death of yeast or fungi for the preparation of a medicament for treating diseases associated with yeast or fungi or for the treatment of proliferative disorders or for preventing apoptosis in certain diseases. Methods are provided to identify compounds which selectively modulate the expression or functionality of said polypeptides in the same or a parallel pathway. Also provided are compounds as well as pharmaceutical compositions, medicaments and vaccines. The invention also comprises new nucleic acid sequences, probes and primers derived thereof, expression vectors and host cells transformed with said vectors, polypeptides and antibodies raised against said polypeptides.

Cette invention a trait à l'utilisation d'acides nucléiques et de polypeptides intervenant dans une voie menant éventuellement à la mort cellulaire programmée de levures ou de champignons, aux fins de la préparation d'un médicament permettant de traiter des états pathologiques liés à des levures ou à des champignons ou de traiter des troubles de prolifération cellulaire ou d'empêcher l'apoptose dans certaines maladies. L'invention concerne également des méthodes d'identification de composés qui modulent de manière sélective l'expression ou la fonctionnalité desdits polypeptides dans la même voie ou dans une voie parallèle. Elle porte, de surcroît, sur des composés ainsi que sur des compositions pharmaceutiques, des médicaments et des vaccins. Elle concerne, en outre, de nouvelles séquences nucléotidiques, des sondes et des amorces dérivées de ces séquences, des vecteurs d'expression et des cellules hôtes transformées par ces vecteurs, des polypeptides et des anticorps contre lesdits polypeptides.

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