Cellular accumulation of phosphonate analogs of hiv protease...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/40 (2006.01) A61K 31/662 (2006.01) C07D 243/04 (2006.01) C07D 403/06 (2006.01) C07D 493/04 (2006.01) C07F 9/02 (2006.01) C07F 9/09 (2006.01) C07F 9/38 (2006.01) C07F 9/62 (2006.01) C07F 9/645 (2006.01) C07F 9/653 (2006.01) C07F 9/655 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01) C12N 9/16 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 2481261

Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

L'invention concerne des composés à substitution phosphonate présentant des propriétés inhibitrices de la protéase du VIH et pouvant être utilisés comme agents thérapeutiques ainsi qu'à d'autres fins industrielles. Ces compositions inhibent l'activité de la protéase du VIH 5 et/ou sont thérapeutiquement utiles pour le traitement du SIDA et d'autres infections virales ainsi que dans des analyses destinées à détecter la protéase du VIH.

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