Certain chemical entities, compositions and methods

Details Certain chemical entities, compositions and methods Certain chemical entities, compositions and methods

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 19/08 (2006.01) A61P 21/04 (2006.01)

Patent

CA 2659336

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.

L'invention concerne des entités chimiques, et des procédés d'utilisation de celles-ci en vue de moduler la myosine, l'actine, la tropomyosine, la troponine C, la troponine I, la troponine T et les muscles du squelette, notamment des fragments et des isoformes de ceux-ci, ainsi que le sarcomère osseux, et des procédés d'utilsation de celles-ci dans le traitement de l'obésité, de la sarcopénie, du syndrome de dépérissement, de la fragilité osseuse, de la cachexie, du spasme musculaire, de la faiblesse musculaire post-chirurgicale et post-traumatique, et pour d'autres indications.

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