Chain-terminated n-vinyl lactam polymers and...

Details Chain-terminated n-vinyl lactam polymers and... Chain-terminated n-vinyl lactam polymers and...

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 31/79 (2006.01) A61K 38/44 (2006.01) A61K 47/32 (2006.01) A61K 47/48 (2006.01) C08F 8/00 (2006.01) C08F 26/06 (2006.01) C08F 26/10 (2006.01)

Patent

CA 2104890

ABSTRACT OF THE DISCLOSURE A water-soluble polyvinyl 5-membered lactam having a molecular weight ranging from about 1000 to about 20,000 and chain-terminated with a compound selected from the group consisting of compounds of the following formulas and (I) Image and (II) Image wherein R and R1 are C1 to C4 alkyl or substituted alkyl; n is 0 to 20; Rn is ethylene; Rm is C1 to C24 alkylene or substituted alkylene; and RIV is C1 to C4 alkyl or substituted alkyl; can be prepared by polymerizing an N- vinyl 5-membered lactam in a liquid solvent-chain terminator compound of the formula (I) or (II) in the presence of a free radical initiator. The lactam polymer so-obtained may be activated and grafted to (conjugated with) a drug or an enzyme to alter the properties thereof.

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