Chemical compounds

Details Chemical compounds Chemical compounds

C - Chemistry, Metallurgy

07

D

167/216, 260/314

C07D 253/06 (2006.01) A61K 31/53 (2006.01) C07C 243/00 (2006.01) C07D 403/10 (2006.01) C07F 9/6521 (2006.01)

Patent

CA 2012004

ABSTRACT Triazine Derivatives Triazine derivatives of formula (I) Image (I) or salts thereof, wherein R1 represents a halogen atom or a group selected from hydroxy; C1-8 alkyl C1-6 alkoxy; C1-3 alkoxy C1-3 alkoxy; phenoxy or phenyl C1-3 alkoxy, wherein the phenyl group is optionally substituted by a halogen atom or a group selected from C1-3 alkyl, C1-3 alkoxy, 01 hydroxy; fluoro C1-3 alkyl; cyano; -CO2R3, wherein R3 represents a hydrogen atom or a C1-4 alkyl group; -CONR4R3, wherein R4 and R5 each independently represents a hydrogen atom or a C1-4 alkyl group, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 7- membered ring, which ring optionally contains one or more atoms selected from an oxygen or a sulphur atom, or a group selected from -NH- or -N(CH3)-; and R2 represents a hydrogen or halogen atom, or a group selected from hydroxy, C1-6 alkyl or C1-6 alkoxy; are inhibitors of the enzyme 5-lipoxygenase. Processes for preparing the triazine derivatives of formula (I) and compositions containing them are also described.

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