Chemical compounds

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 59/72 (2006.01) A61K 31/165 (2006.01) A61K 31/192 (2006.01) A61K 31/382 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07C 43/295 (2006.01) C07C 233/25 (2006.01) C07C 235/34 (2006.01) C07C 317/22 (2006.01) C07D 207/333 (2006.01) C07D 211/60 (2006.01) C07D 309/22 (2006.01) C07D 335/02 (2006.01) C07F 9/142 (2006.01)

Patent

CA 2533812

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. Formula (I) including salts, solvates, and pharmacologically functional derivatives thereof wherein R1is OH; each of R2 and R4 independently are selected from OH, alkyl, or halogen; each of p and q independently are selected from 0, 1, or 2; R3 is -(Y)z-R6; z is 0 or 1; Y is -C=C- or CR6=CR1-; X is -(CH2)n- where n is 0, 1, 2, or 3, -C(R9)2-, -O-,or -S-.

La présente invention concerne de nouveaux composés ayant une pluralité d'utilisations thérapeutiques, plus particulièrement de nouveaux composés d'alkylidène cycliques substitués qui sont particulièrement utiles pour moduler de façon sélective le récepteur d'oestrogène.

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