Chemical compounds

Details Chemical compounds Chemical compounds

C - Chemistry, Metallurgy

07

D

C07D 498/20 (2006.01) A61K 31/5383 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2691485

In one aspect, the present invention relates to compounds of Formula (I) and to pharmaceutically acceptable sa lts thereof, wherein: n is 1 to 4; and R3 in each occurrence is independently selected from -X-R5, -W-R6, -C(O)-N(R3a)-S(O)2-R3b, -C(R3a)=N-R3y, -C(R3a)=N-N(R3a)-C(O)-R3b, -C(R3a)=N-N(R3a)-C(O)2-R3b, - C(R3a)=N-N(R3y)2, -C(R3a)=N-N(R3a)-C(O)-N(R3y)2, C(N(R3a)2)=N-R3y, -C(N(R3a)2)=N-OR3y, -C(N(R3a)2)=N-C(O)-R3b, -C(N(R3a)2=N- S(O)2-R3b, C(N(R3a)2)=N-CN, -N=C(R3y)2, -N(R3a)-S(O)2-N(R3y)2, -N(R3a)-N(R3y)2, -N(R3a)-C(O)-N(R3y)2, -N(R3a)-C(O)- N(R3a)-S(O)2-R3b, -N(R3a)-C(R3a)=N(R3y), -N(R3a)- C(R3a)=N-OR3y, -N(R3a)-C(R3a) =N-C(O)-R3b, -N(R3a)-C(R3a)=N-S(O)2R-3b, -N(R3a)- C(R3a)=N-CN, -N(R3a)-C(N(R3a)2)=N-R3y, -N(R3a)-C(N(R3a)2)=N-OR3y, -N(R3a)-C(N(R3a)2)=N-C(O)-R3b, -N(R3a)-C(N(R33a)2)- N-S(O)2-R3b, -N(R3a)-C(N(R3a)2)-N-CN, -O-C(O)-R3b, and -Si(R3b)3; to methods of using them to treat bacterial infections, and to methods for their preparation.

Dans un aspect, l'invention concerne des composés de formule (I) : (formule), des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des méthodes d'utilisation de ces composés dans le traitement des infections bactériennes et des procédés de préparation associés.

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