Chemical compounds and pharmaceutical compositions as...

Details Chemical compounds and pharmaceutical compositions as... Chemical compounds and pharmaceutical compositions as...

C - Chemistry, Metallurgy

07

D

C07D 263/56 (2006.01) A61K 31/16 (2006.01) A61P 19/02 (2006.01) A61P 33/06 (2006.01) C07C 233/31 (2006.01) C07C 255/29 (2006.01) C07C 255/44 (2006.01) C07C 255/46 (2006.01) C07C 271/12 (2006.01) C07C 271/16 (2006.01) C07C 271/24 (2006.01) C07C 317/44 (2006.01) C07C 317/46 (2006.01) C07D 205/04 (2006.01) C07D 207/08 (2006.01) C07D 211/66 (2006.01) C07D 223/08 (2006.01) C07D 223/12 (2006.01) C07D 239/08 (2006.01) C07D 271/10 (2006.01) C07D 277/28 (2006.01) C07D 277/64 (2006.01) C07D 277/82 (2006.01) C07D 295/

Patent

CA 2448418

The present invention relates to coumponds of formula (I) (in which X1 is- NHC(R1)(R2)X3 or -NHX4 and the other variables are as defined in the claims) and the pharmaceutically acceptable salts and N-oxides therof, useful as selective cathepsin S inhibitors, their uses as therapeutic agents and the methods for their making. Formula (I):

L'invention concerne de nouveaux inhibiteurs sélectifs de cathepsine S, leurs sels pharmaceutiquement acceptables, leurs <I>N</I>-oxydes, leurs utilisations en tant qu'agents thérapeutiques ainsi que des méthodes d'élaboration desdits inhibiteurs.

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