A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4709 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2522535
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infections of target cells by a human immunodeficiency virus (HIV).
L'invention concerne des composés hétérocycliques constitués d'un atome azote de coeur entouré de trois groupes pendants, dans lesquels deux des trois groupes pendants sont de préférence benzimidazolyl méthyle et tétrahydroquinolyle, et le troisième groupe pendant contient N et il contient facultativement des cycles additionnels. Les composés se fixent aux récepteurs de la chimiokine, y compris CXCR4 et CCR5, et ils présentent des effets protecteurs contre l'infection de cellules cibles par un virus d'immunodéficience humaine (VIH).
Atsma Bem
Bogucki David
Bridger Gary J.
Crawford Jason
Di Fluri Maria Rosaria
Anormed Inc.
Fetherstonhaugh & Co.
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