Chimeric molecules for cleavage in a treated host

Details Chimeric molecules for cleavage in a treated host Chimeric molecules for cleavage in a treated host

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/475 (2006.01) C07K 14/485 (2006.01) C07K 19/00 (2006.01) C12N 15/18 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2475388

The present invention relates to chimeric molecules containing component molecules that are linked together in a non-naturally occurring manner where the linker contains at least one enzyme cleavage site, and the nezyme cleavage site is engineered to be cleaved by an enzyme in a treated subject. The present invention also relates to compositions and kits containing the chimeric molecules, methods of making the chimeric molecules in a production host, methods of using the present chimeric molecules for diagnostic, prophylactic, therapeutic, and nutritional purposes in subjects requiring such.

L'invention concerne des molécules chimériques contenant des molécules composantes liées ensemble de manière non naturelle, le liant contenant au moins un site de clivage d'enzyme et ledit site étant mis au point par génie génétique afin d'être clivé au moyen d'une enzyme chez un sujet traité. L'invention concerne également des compositions et des kits contenant lesdites molécules chimériques, des méthodes de production de ces molécules chimériques dans un hôte de production, et des méthodes d'utilisation des molécules chimériques à des fins diagnostiques, prophylactiques, thérapeutiques et nutritionnelles chez des sujets qui en ont besoin.

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