Chimeric oligomeric compounds and their use in gene modulation

Details Chimeric oligomeric compounds and their use in gene modulation Chimeric oligomeric compounds and their use in gene modulation

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01)

Patent

CA 2504720

Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.

Compositions oligomères comprenant un premier et un second oligomère dans lesquelles au moins une partie du premier oligomère peut s'hybrider avec au moins une partie du second oligomère, au moins une partie du premier oligomère est complémentaire d'un acide nucléique cible choisi avec lequel il peut s'hybrider, et au moins le premier ou le second oligomère comprend au moins un nucléotide renfermant une composition organique chimère. Sont également décrites des compositions oligomère/protéine comprenant un oligomère complémentaire d'un acide nucléique cible choisi avec lequel il peut s'hybrider et au moins une protéine renfermant au moins un complexe de silençage induit par ARN, avec au moins un nucléotide qui comprend une composition organique chimère.

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