Chitosan biopolymer for the topical delivery of active agents

Details Chitosan biopolymer for the topical delivery of active agents Chitosan biopolymer for the topical delivery of active agents

A - Human Necessities

61

K

A61K 8/73 (2006.01) A61K 31/74 (2006.01) A61K 47/36 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2394901

The present invention relates to a carrier base for the topical delivery of an active agent comprising a high viscosity chitosan biopolymer. The invention further relates to a method of controlling the release of an active agent from a carrier base, comprising as a carrier base a high viscosity chitosan; providing the active agent; and mixing the active agent and the chitosan. Preferably, the carrier base comprises a high viscosity chitosan having a molecular weight of at least about 100,000 Dalton, more preferably at least about 250,000 Dalton and most preferably at least about 300,000 Dalton. In other preferred embodiments the chitosan has a concentration of at least about 2 weight %.

La présente invention concerne une base de transport utilisée dans l'administration par voie topique d'un agent actif comprenant un biopolymère de chitosane à viscosité élevée. L'invention concerne également une méthode permettant de commander la libération d'un agent actif d'une base de transport, comprenant comme base de transport un chitosane à viscosité élevée, consistant à générer l'agent actif, et à mélanger l'agent actif et le chitosane. De préférence, la base de transport comprend un chitosane à viscosité élevée possédant un poids moléculaire d'au moins 100 000 Dalton environ, préférablement d'au moins 250 000 Dalton environ, et plus préférablement d'au moins 300 000 Dalton environ. Dans d'autres modes de réalisation, le chitosane a une concentration d'au moins 2 % en poids environ.

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