C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/04 (2006.01) A61K 31/23 (2006.01) A61K 31/405 (2006.01) C07C 235/76 (2006.01) C07D 209/20 (2006.01) C12P 17/10 (2006.01)
Patent
CA 2074999
91/CAD40 18503X TITLE OF THE INVENTION CHOLESTEROL-LOWERING AGENTS ABSTRACT OF THE INVENTION This invention relates to compounds of structural formula (I): Image (I) which are squalene synthase inhibitors and thus useful as cholesterol lowering agents, and antifungal agents, These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
Bergstrom James D.
Diez Maria T.
Harris Guy H.
Huang Leeyuan
Jenkins Rosalind F.
Bergstrom James D.
Diez Maria T.
Harris Guy H.
Huang Leeyuan
Jenkins Rosalind F.
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