Chromane and chromene derivatives and uses thereof

Details Chromane and chromene derivatives and uses thereof Chromane and chromene derivatives and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 311/58 (2006.01)

Patent

CA 2648894

Methods of preparing compounds of formula (I) or pharmaceutically acceptable salts thereof are provided wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

L'invention concerne des procédés de préparation de composés représentés par la formule (I), ou de sels de classe pharmaceutique de ceux-ci. R1, R2, R3, R4, x, m, n, et Ar correspondent chacun à la définition et aux classes et sous-classes indiquées dans la description. Ces composés sont des agonistes ou des agonistes partiels du sous-type 2C des récepteurs cérébraux de la sérotonine. Ces composés, ainsi que les compositions les contenant, conviennent pour le traitement de divers troubles du système nerveux central, comme par exemple la schizophrénie.

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