Chromene derivatives and salts thereof, and pharmaceuticals...

Details Chromene derivatives and salts thereof, and pharmaceuticals... Chromene derivatives and salts thereof, and pharmaceuticals...

C - Chemistry, Metallurgy

07

D

C07D 311/58 (2006.01) A61K 31/35 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2249049

Disclosed are chromene derivatives represented by the following formula: (see fig. I) wherein R1s represent alkyl, alkoxy or like groups, R2 represents a hydrogen atom or an alkyl group, R3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.

Divulgation de dérivés de chromène, et de leurs sels, représentés par la formule suivante : (voir fig. I), dans laquelle R1 représente un alkyle, un alcoxy ou des groupements semblables, R2 représente un atome d'hydrogène ou un groupement alkyle, R3 est un phényle, un naphthyle ou un hétérocycle substitué ou non substitué, et m représente un nombre entier entre 0 et 4, ainsi que de produits pharmaceutiques en contenant comme ingrédients actifs. Les dérivés de chromène et leurs sels sont très efficaces pour inhiber la formation de produits terminaux de la glycosylation avancée et sont utiles comme moyen pour prévenir et traiter les complications du diabète.

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