Chromenoneindoles

Details Chromenoneindoles Chromenoneindoles

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2520892

The invention relates to the chromenone indole derivatives of formula (I), wherein R1, R2, R3, R, A and B are defined as in claim 1 and to the pharmaceutically useful prodrugs, derivatives, solvates, stereoisomers and salts thereof. The inventive substances have particular effects on the central nervous system, in particularly they are 5 HT reuptake inhibitors and 5 HTx agonists and/or antagonists. They are characterized by an especially good bioavailability and excellent inhibition of 5 HT reuptake.

L'invention concerne des dérivés de chromenoindole de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R, A et B ont les désignations spécifiées dans la revendication 1, ainsi que les promédicaments, dérivés, solvates, stéréoisomères et sels pharmaceutiquement acceptables de ces dérivés. Ces composés exercent des effets particuliers sur le système nerveux central, principalement des effets inhibant la reprise 5 HT et agonistes et/ou antagonistes 5 HT¿x ?. Ils se caractérisent par une biodisponibilité particulièrement élevée, et une inhibition particulièrement élevée de la reprise 5 HT.

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