Chromosome 12 gene and gene products related to alzheimer's...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2203069

The present invention discloses nucleic acid molecules encoding genes involved in CNS disorders such as Alzheimer's disease and epilepsy. Also disclosed are gene products, vectors and host cells suitable for expression of such gene products. Methods are providing for detecting the presence of a gene involved in Alzheimer's disease in human subjects and for treating humans suffering from Alzheimer's disease. Furthermore, markers which are associated with Alzheimer's disease are disclosed. Methods in kits for the detection of Alzheimer disease in a subject are additionally provided.

La présente invention divulgue des molécules d'acide nucléique codant des gènes qui interviennent dans les troubles du SNC, notamment dans la maladie d'Alzheimer et dans l'épilepsie. L'invention divulgue également des produits génétiques, des vecteurs et des cellules hôtes appropriés pour l'expression de produits génétiques de ce type. Des méthodes sont présentées pour déceler la présence d'un gène impliqué dans la maladie d'Alzheimer chez l'homme et pour le traitement des personnes souffrant de la maladie d'Alzheimer. De plus, on divulgue des marqueurs qui sont associés à la maladie d'Alzheimer. Enfin, on présente également des méthodes sous forme de trousses pour la détection de la maladie d'Alzheimer chez un sujet.

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