Chromosome 18q loss and prognosis in colorectal cancer

Details Chromosome 18q loss and prognosis in colorectal cancer Chromosome 18q loss and prognosis in colorectal cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2140057

We have developed procedures to examine the status of chromosome 18q with polymorphic genetic markers and DNA from formalin-fixed, paraffin- embedded tumors. Allelic loss of chromosome 18q was assessed in 145 consecutively resected stage II or III colorectal carcinomas. Among patients with stage II disease, the five-year survival rate was 93 percent in those whose tumor had no evidence of allelic loss of chromosome 18q and 54 percent in those with allelic loss; among patients with stage III disease, survival was 52 and 38 percent, respectively.

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