Clostridium difficile toxins as mucosal adjuvants

Details Clostridium difficile toxins as mucosal adjuvants Clostridium difficile toxins as mucosal adjuvants

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/08 (2006.01) A61K 39/106 (2006.01) A61K 39/385 (2006.01) C07K 14/33 (2006.01)

Patent

CA 2226339

The invention features methods and compositions for inducing protective and/or therapeutic immune responses to an antigen in a mammal. In these methods, an antigen is administered to the mammal with a toxin of a Clostridium (e.g., C. difficile), or a fragment or derivative thereof having adjuvant activity.

L'invention concerne des procédés et des compositions pour induire des réponses immunes de nature protectrice et/ou thérapeutique dirigées contre un antigène administré à un mammifère. Dans ces procédés, l'antigène est administré au mammifère conjointement avec une toxine de Clostridium (par exemple C. difficile) ou des fragments ou dérivés de cette toxine, ayant une activité d'adjuvant.

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