Cns-active hexapeptides with an antiamnesic effect

Details Cns-active hexapeptides with an antiamnesic effect Cns-active hexapeptides with an antiamnesic effect

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/695 (2006.01)

Patent

CA 2025941

- 1 - HOE 89/F 316 Abstract of the disclosure Novel CNS-active hexapeptides with an antiamnesic effect The present invention relates to hexapeptides of the formula I R1-A1-A2-A3-A4-A5-A6-NH(CH2)n-NH2 (I) in which R1 is Z, formyl or (subst.) alkanoyl; A1 is Met, Met(O) or Met(O2), all of which can be in the L sr D form; A2 is Glu, D-Glu, Ala or pyroglutamyl; A3 is His, Ala, Phe or D-Lys; A4 is the residue of a neutral aliphatic or aromatic .alpha.- amino acid; A5 is Lys or D-Lys; A6 is (subst.) Phe and n is an integer from 4 to 10. A process for the preparation thereof, the use thereof as medicines, and pharmaceutical agents containing these are described.

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