Collagen-based injectable drug delivery system and its use

Details Collagen-based injectable drug delivery system and its use Collagen-based injectable drug delivery system and its use

A - Human Necessities

61

K

A61K 47/00 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01)

Patent

CA 2140053

Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composition also includes a flexible chain polymer which is similarly charged to the precrosslinked collagen. This flexible chain polymer is enclosed in the matrix as well when the matrix forms and alters the effective porosity of the matrix. The drug diffuses out of the matrix at a rate which depends upon the matrix's effective porosity.

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