Combination of an hmg coa reductase inhibitor and a squalene...

A - Human Necessities – 61 – K

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167/179

A61K 31/00 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2007643

HX23 Abstract COMBINATION OF AN HMG CoA REDUCTASE INHIBITOR AND A SOUALENE SYNTHETASE INHIBITOR AND METHOD FOR LOWERING SERUM CHOLESTEROL USING SUCH COMBINATION Abstract of the Disclosure A pharmaceutical combination is provided which includes an inhibitor of the enzyme 3- hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, such as lovastatin, pravastatin or velostatin, and an inhibitor of the enzyme squalene synthetase. A method for reducing serum cholesterol or inhibiting formation of or treating atherosclerosis using the above combination is also provided.

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