Combination of glycoisoforms for the treatment or prevention...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/505 (2006.01) A61K 38/18 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2629304

The invention relates to a combination of erythropoietin glycoisoforms, in which said glycoisoforms can comprise between 4 and 10 sialic acid molecules per molecule of erythropoietin. The aforementioned combination of glycoisoforms can be used for the treatment or prevention of septicemia/sepsis. The invention also relates to a pharmaceutical composition comprising the above-mentioned combination, a cell line that produces a combination of erythropoietin glycoisoforms, methods of obtaining the cell line, a method of producing the combination of glycoisoforms and methods for the treatment and prevention of septicemia/sepsis.

L'invention porte sur une combinaison de glyco-isoformes d'érythropoiétine, dans laquelle lesdites glyco-isoformes peuvent comprendre entre 4 et 10 molécules d'acide sialique par molécule d'érythropoiétine. Ladite combinaison de glyco-isoformes peut être utilisée dans le traitement ou la prévention de la septicémie/sepsis. L'invention porte également sur une composition pharmaceutique qui comprend ladite combinaison, sur une lignée cellulaire qui produit une combinaison de glyco-isoformes d'érythropoietine, sur des procédés d'obtention de ladite lignée cellulaire, sur un procédé de production de ladite combinaison de glyco-isoformes et sur des méthodes de traitement et de prévention de la septicémie/sepsis.

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