C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) C12N 15/113 (2010.01)
Patent
CA 2683109
The invention provides a method of treating neoplastic disease in a subject, said method comprising the simultaneous, sequential or separate, administration to said subject of an effective amount of (i) an inhibitor of a first EGF, e.g. HB-EGF and (ii) an inhibitor of a second EGF, e.g. AREG. Also described are novel synergistic combinations of of EGF inhibitors with topoisomerase inhibitors which attenuate tumour cell growth. Further described are novel anti AREG antibodies.
L'invention concerne un procédé de traitement d'une maladie néoplasique chez un sujet. Ledit procédé comporte l'administration simultanée, séquentielle ou séparée audit sujet d'une quantité efficace (i) d'un inhibiteur d'un premier EGF, par exemple HB-EGF, et (ii) d'un inhibiteur d'un second EGF, par exemple AREG. L'invention concerne également de nouvelles combinaisons synergiques d'inhibiteurs de EGF avec des inhibiteurs de topoisomérase qui diminuent la croissance cellulaire tumorale. L'invention concerne en outre de nouveaux anticorps anti-AREG.
Brown Jill
Jaquin Thomas
Johnston James
Morgan Nuala
Olwill Shane
Fusion Antibodies Limited
Gowling Lafleur Henderson Llp
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