Combination therapy comprising the use of et-743 and...

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61K 31/704 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2545043

Methods of treating a human body for cancer are provided. In one aspect, a therapeutic amount of doxorubicin is administered in combination with ET-743 in a dose range between 0.5 and 1 mg/m2. In a related aspect, an effective therapeutic amount of ET-743 is administered in combination with doxorubicin in a dose range between 40 and 80 mg/m2.

La présente invention concerne des procédés permettant de traiter un patient humain atteint d'un cancer. Dans un aspect de cette invention, une quantité thérapeutique de doxorubicine est administrée conjointement avec la ET-743 (ectéinascidine) dans une marge posologique comprise entre 0,5 et 1 mg/m?2¿. Dans un autre aspect de cette invention, une quantité thérapeutique efficace de ET-743 est administrée conjointement avec la doxorubicine dans une marge posologique comprise entre 40 et 80 mg/m?2¿.

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