Combinations for cardiovascular indications

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 31/095 (2006.01) A61K 31/365 (2006.01) A61K 31/397 (2006.01) A61K 31/4178 (2006.01) A61K 31/55 (2006.01) A61K 31/554 (2006.01) A61K 31/575 (2006.01) A61K 31/585 (2006.01) A61K 31/77 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2356515

The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia and atherosclerosis. Combinations disclosed include an ileal bile acid transport inhibitor combined with a cholesteryl ester transport protein (CETP) inhibitor, a fibric acid derivative, a nicotinic acid derivative, a microsomal triglyceride transfer protein inhibitor, a cholesterol absorption antagonist, a phytosterol, a stanol, an antihypertensive agent, or others. Further combinations include a CETP inhibitor with a fibric acid derivative, a nicotinic acid derivative, a bile acid sequestrant, a microsomal triglyceride transfer protein inhibitor, a cholesterol absorption antagonist, or others.

La présente invention concerne des combinaisons de composés de thérapie cardio-vasculaire utilisées pour la prévention ou le traitement de troubles cardio-vasculaires telles que l'hypercholestérolémie et l'athérosclérose. Cette invention fait intervenir des combinaisons comprenant un inhibiteur de transport de l'acide biliaire iléal combiné avec un inhibiteur de la protéine de transport de l'ester de cholestéryle cholesteryl ester transport protein (CETP), un dérivé de l'acide fibrique, un dérivé de l'acide nicotinique, un inhibiteur de la protéine de transfert du triglycéride microsomal, un antagoniste d'absorption du cholestérol, un phytostérol, un stanol, un agent hypotenseur, ou autres. D'autres combinaisons font intervenir un inhibiteur de la CETP avec un dérivé de l'acide fibrique, un dérivé de l'acide nicotinique, un agent séquestrant de l'acide biliaire, un inhibiteur de la protéine de transfert du triglycéride microsomal, un antagoniste d'absorption du cholestérol, ou autres.

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