Combinatorial synthesis and high-throughput screening of a...

Details Combinatorial synthesis and high-throughput screening of a... Combinatorial synthesis and high-throughput screening of a...

C - Chemistry, Metallurgy

07

C

C07C 279/28 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07B 61/00 (2006.01) C07C 237/20 (2006.01) C07C 275/24 (2006.01) C07C 275/42 (2006.01) C07D 213/72 (2006.01) C07D 215/14 (2006.01) C07D 233/64 (2006.01) C07D 295/15 (2006.01) C07D 307/54 (2006.01) C07D 307/66 (2006.01) C07D 453/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2220576

This invention relates to certain novel chemical compounds which inhibit the binding of a Rev protein to a Rev response element. These compounds reduce the binding activity of the protein to the response element by at least about 50 % and preferably 90 % or more. Another embodiment relates to a method for inhibiting the binding of a Rev protein to a Rev response element by administering one of these compounds to a subject in vitro.

L'invention porte sur certains composés chimiques nouveaux inhibant la fixation d'une protéine Rev (régulatrice du VIH) sur son élément de réponse. Ces composés réduisent l'activité de fixation de la protéine sur l'élément de réponse d'au moins 50 % et même de 90 % ou plus. Elle porte en outre sur un procédé d'inhibition de la fixation d'une protéine Rev à son élément de réponse consistant à administrer in vitro l'un desdits composés à un sujet.

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