Combretastatin a-4 derivatives having antineoplastic activity

Details Combretastatin a-4 derivatives having antineoplastic activity Combretastatin a-4 derivatives having antineoplastic activity

C - Chemistry, Metallurgy

07

C

C07C 49/83 (2006.01) A61K 31/09 (2006.01) A61K 31/12 (2006.01) A61K 31/137 (2006.01) A61K 31/165 (2006.01) A61K 31/221 (2006.01) A61K 31/36 (2006.01) A61P 35/00 (2006.01) C07C 43/295 (2006.01) C07C 49/755 (2006.01) C07C 211/46 (2006.01)

Patent

CA 2468399

Compounds are disclosed that are designed to mimic the activity of combretastatin A-4 based on chalcone, aurone, or indanone structures, or involving benzoquinone or quinone rings. The anti-cancer activity of exemplified compounds is demonstrated in a range of in vitro and in vivo assays.

L'invention concerne des composés destinés à imiter les effets de la combretastatine A-4, qui comportent des structures de chalcone, d'aurone, ou d'indanone, ou qui présentent des cycles benzoquinone ou quinone. L'effet anticancéreux des composés de l'invention est démontré dans des tests in vitro et in vivo.

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