C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 9/16 (2006.01) C12N 11/02 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) C12N 15/55 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2089139
ABSTRACT OF THE DISCLOSURE Complex hybrid proteins comprising the light chains and the variable regions and certain constant domains of the heavy chains of immunoglobulins and another homo- or heterodimeric protein, a method for preparing them, as well as their applications as diagnostic agent, as agent intended for therapeutic use or as reagent which can be used in medical imaging. The hybrid protein of the type comprising an immunoglobulin fragment fused with another protein P, consists of a complex hybrid sequence comprising: ? a basic unit U consisting of: ? two different peptide chains SU1 and SU2, SU1 comprising the variable and constant regions of a light immunoglobulin chain and SU2 comprising at least the variable regions and the CH1 domain of a heavy immunoglobulin chain, the peptide chains SU1 and SU2 are bound to each other by means of at least one disulphide bridge and ? at least one functional fragment of one of the two subunits of a dimeric protein P, fused via its N- terminal end to one of the peptide chains SU1 or SU2, ? which basic unit U is associated with another basic unit U', which is identical or different from the unit U, by means of the protein P subunits or a fragment thereof.
Boulain Jean-Claude
Ducancel Frederic
Gillet Daniel
Menez Andre
No associations
LandOfFree
Complex hybrid proteins, method for preparing them, their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Complex hybrid proteins, method for preparing them, their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Complex hybrid proteins, method for preparing them, their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1873047