Complex of human growth hormone and zinc and use

A - Human Necessities – 61 – K

Patent

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A61K 47/02 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/27 (2006.01) A61K 47/34 (2006.01) C07K 14/61 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2248390

The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.

La présente invention porte sur un complexe d'hormone de croissance humaine et de zinc, renfermant une hormone de croissance humaine et du zinc, à un rapport molaire d'environ 1:1,6 à environ 1:2,4; préparation à libération prolongée, renfermant le complexe d'hormone de croissance humaine et de zinc, ainsi qu'un polymère biodégradable; elle possède un taux de piégeage élevé pour l'hormone de croissance humaine et permet une libération prolongée stable, avec suppression de l'emballement initial.

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