C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/35 (2006.01) C12N 9/02 (2006.01)
Patent
CA 2647096
The main subject of the present invention is the use of complexes of NADP with the protein MabA, or with a derived protein, and more particularly the crystallographic coordinates of these proteins in the frame of said complexes, within the framework of the implementation of methods for designing and screening ligands of these proteins, and advantageously ligands inhibiting the enzymatic activity of these proteins, namely antibiotics capable of being used within the framework of the treatment of mycobacteriosis.
Le sujet principal de la présente invention concerne l'utilisation de complexes de NADP avec la protéine MabA, ou avec une protéine dérivée, et plus particulièrement les coordonnées cristallographiques de ces protéines dans le cadre de ces complexes, dans le cadre de travail de la mise en oeuvre de méthodes de conception et de criblage de ligands de ces protéines, et de préférence de ligands inhibant l'activité enzymatique de ces protéines, à savoir des antibiotiques pouvant être utilisés dans le cadre du traitement d'une mycobactériose.
Cohen-Gonsaud Martin
Daffe Mamadou
Ducasse-Cabanot Stephanie
Labesse Gilles
Quemard Annaik
Centre National de La Recherche Scientifique
Goudreau Gage Dubuc
LandOfFree
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