A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/32 (2006.01) A61K 45/08 (2006.01) A61K 47/34 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2263411
A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer network. The polymer network includes at least one responsive polymer component, said responsive component capable of aggregation in solution in response to an environmental stimulus and at least one structural component, said structural component exhibiting self-repulsive interactions over use conditions. The responsive component is randomly bonded to said structural component and the polymer network characterized in that it viscosifies in response to said environmental stimulus. The composition further includes a pharmaceutically active agent which imparts a pharmaceutic effect, said carrier and said agent disposed within an aqueous-based medium. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.
Une composition pharmaceutique inclut un véhicule pharmaceutiquement acceptable comprenant un réticulat polymérique capable de gélification thermique réversible. Le réticulat polymérique inclut au minimum un composant de polymère sensible, ledit composant de polymère sensible pouvant s'agréger dans une solution en réponse à une stimulation, et au minimum un composant structurel, ledit composant structurel manifestant des interactions d'auto-répulsion dans des conditions d'utilisation. Le composant sensible est fixé de manière aléatoire audit composant structurel et le réticulat polymérique se caractérise par le fait qu'il se transforme en gel en réponse à ladite stimulation environnementale. La composition comprend en outre un agent pharmaceutiquement actif qui produit un effet pharmaceutique, ledit véhicule et ledit agent étant disposés à l'intérieur d'un milieu aqueux. La composition peut être utilisée pour administrer l'agent pharmaceutique à travers des membranes cutanées, otiques, rectales, vaginales, ophtalmiques, oesophagiennes ou pituitaires.
Bromberg Lev
Kearney Marie
Luczak Scott
Orkisz Michal
Ron Eyal S.
Blake Cassels & Graydon Llp
Bromberg Lev
Kearney Marie
Luczak Scott
Medlogic Global Corporation
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