Composition, method and kit for potentiating antitumor...

A - Human Necessities – 61 – K

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A61K 31/53 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2087540

A composition for potentiating the antitumor activity of tegafur and reducing the adverse effects, comprising a compound represented by general formula (I) Image wherein X represents halogen or cyano and oxonic acid or a pharmaceutically acceptable salt thereof. A method and kit practicing the method are also disclosed. A composition for curing tumors is also disclosed comprising tegafur, a compound represented by formula (I) and oxonic acid or a pharmaceutically acceptable salt thereof as well as a method and kit therefor.

Composition servant à potentialiser l'activité antitumorale du tegafur et à atténuer ses effets indésirables, comportant un composé représenté par une formule générale (I) Image dans laquelle X représente l'halogène ou le groupe cyano et l'acide oxonique ou un de ses sels pharmacologiquement acceptables. Une méthode et une trousse appliquant la méthode sont également divulguées. Une composition pour guérir les tumeurs est également divulguée; celle-ci comprend du tegafur, un composé représenté par la formule (I) et l'acide oxonique ou un de ses sels pharmacologiquement acceptables ainsi qu'une méthode et une trousse.

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