C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 39/21 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2476403
The present invention provides an approach for developing an algorithm for determining the effectiveness of anti-viral drugs based on a comprehensive analysis of paired phenotypic and genotypic data guided by phenotypic clinical cut-offs. In one aspect, the algorithm allows one to provide a patient with effective treatment. It helps predict whether an infected individual will respond to treatment with an anti-viral compound, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects. Also, by avoiding the administration of ineffective drugs, considerable time and money is saved.
La présente invention concerne une approche pour mettre au point un algorithme permettant de déterminer l'efficacité de médicaments antiviraux, sur la base d'une analyse complète de données de phénotype et de génotype appariées, guidée par des relevés cliniques de phénotype. Selon un aspect, l'algorithme permet d'offrir un traitement efficace à un patient et aide à prévoir si un individu infecté va répondre à un traitement avec un composé antiviral, permettant alors d'établir un schéma posologique de traitement efficace sans faire subir au patient des effets secondaires non inévitables. On économise également beaucoup de temps et d'argent en évitant d'administrer des médicaments non efficaces.
Chappey Colombe
Parkin Neil T.
Petropoulos Christos J.
Monogram Biosciences Inc.
Osler Hoskin & Harcourt Llp
Virologic Inc.
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