Compositions and methods for effecting the levels of high...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) A01N 63/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07K 16/40 (2006.01) C12N 9/20 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2363486

Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the tryacylglycerol lipase family or which effect the enzymatic activity of the enzyme.

La présente invention concerne des compositions et des procédés permettant d'élever le taux de cholestérol des HDL et des apolipoprotéines AI chez un patient et de réduire le taux de cholestérol des VLDL et des LDL chez un patient. Ces compositions et ces procédés agissent sur l'expression d'un gène, LIPG, qui code une lipase qui fait partie de la famille des triacylglycériol lipases ou qui agit sur l'activité enzymatique de cette enzyme.

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