Compositions and methods for eliciting an immune response to...

A - Human Necessities – 23 – J

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A23J 1/00 (2006.01) A61K 39/00 (2006.01) C07K 14/21 (2006.01) C12N 15/09 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2477170

Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest. Methods of eliciting an immune response by administration of such compositions are also provided.

L'invention concerne des compositions destinées à provoquer une réponse immunitaire contre des infections bactériennes à Gram négatif et procédés destinés à fabriquer de telles compositions. Cette composition comprend une piline glycosylée, cette piline étant glycosylée au moyen d'antigène O d'une cible de bactérie à Gram négatif cible d'intérêt. L'invention concerne également des procédés destinés à provoquer une réponse immunitaire par administration de ces compositions.

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