C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C07H 21/02 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2626584
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell
L'invention porte sur un acide ribonucléique double brin (ARNdb) permettant d'inhiber l'expression du gène Nav1.8 (gène Nav1.8), et comprenant un brin antisens comportant une séquence nucléotidique possédant moins de 25 nucléotides dans sa longueur et qui est sensiblement complémentaire à au moins une partie du gène Nav1.8. L'invention porte également sur une composition pharmaceutique comprenant l'ARNdb et un excipient acceptable d'un point de vue pharmaceutique. L'invention porte aussi sur des méthodes de traitement de maladies provoquées par l'expression du gène Nav1.8, ces méthodes utilisant la composition pharmaceutique, ainsi que sur des méthodes visant à inhiber l'expression du gène Nav1.8 dans une cellule.
Frank-Kamenetsky Maria
Geick Anke
Hadwiger Philipp
Roehl Ingo
Sah Dinah Wen-Yee
Alnylam Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
Compositions and methods for inhibiting expression of nav1.8... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for inhibiting expression of nav1.8..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting expression of nav1.8... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2065834