Compositions and methods for modulating connexin hemichannels

Details Compositions and methods for modulating connexin hemichannels Compositions and methods for modulating connexin hemichannels

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/05 (2006.01) A61K 38/07 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2474788

Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.

L'invention concerne des compositions et des procédés pour la modulation de la fonction des demi-canaux dans une cellule, un tissu ou un organe. L'invention porte également sur des cribles spécifiques utiles pour la détection desdits composés, notamment de ceux pouvant moduler la phosphorylation des connexines. Des méthodes thérapeutiques destinées à prévenir ou à traiter des états influencés par la fonction des demi-canaux chez un mammifère, tels que l'arythmie cardiaque.

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