Compositions and methods for modulating gated ion channels

Details Compositions and methods for modulating gated ion channels Compositions and methods for modulating gated ion channels

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61K 31/496 (2006.01) A61K 31/517 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 215/52 (2006.01) C07D 239/74 (2006.01) C07D 239/88 (2006.01) C07D 239/91 (2006.01) C07D 239/94 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2634491

Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4- position via N(H), C(O) or O moieties. Image

L'invention concerne des composés de quinoléine et de quinazoline qui modulent l'activité des canaux ioniques commandés par porte. Les composés qui modulent ces canaux ioniques commandés par porte sont utilisés dans le traitement de maladies et de troubles relatifs à la douleur, l'inflammation, au système neurologique, au système gastro-intestinal et au système génito-urinaire. On mentionne comme composés préférés de l'invention des dérivés de la quinoléine ou de la quinazoline substitués en position 4, via des fractions N(H), C(O) ou O.

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