C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/04 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2652109
The present invention relates to compounds of the Formula (I),(II), (III), (IV) or (V) useful to modulate the activity of gated ion channels. The invention further relates to methods wherein said compounds are used to modulate gated ion channels comprised of at least one subunit which is a member of the DEG/ENaC, P2X or TRPV gene superfamilies. The activity of the gated ion channels which are modulated by compounds I-V are associated with pain, inflammatory disorders or neurological disorders.
L'invention concerne des composés de formule (I), (II), (III), (IV) ou (V) convenant pour la modulation de canaux ioniques commandés par porte. Elle concerne également des méthodes dans lesquelles lesdits composés s'utilisent pour moduler des canaux ioniques commandés par porte comprenant au moins une sous-unité faisant partie des superfamilles de gènes DEG/ENaC, P2X ou TRPV. L'activité des canaux ioniques commandés par porte qui sont modulés par des composés de formule I-V est associée à la douleur, à des troubles inflammatoires ou à des troubles neurologiques.
Dechaux Elsa Amandine
Dyke Hazel Joan
Gan Zhonghong
Price Stephen
Vohra Rahul
Borden Ladner Gervais Llp
Painceptor Pharma Corporation
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