C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2607291
The present invention provides a newly identified B7 receptor, zB7Rl that functions as lymphocyte inhibitory receptor, which is a PD-I -like molecule and is expressed on T cells. The present invention also provides the discovery of zB7Rl's ability to bind to CD155. Methods and compositions for modulating zB7Rl -mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
L'invention concerne un récepteur B7 nouvellement identifié, zB7R1 qui fonctionne en tant que récepteur inhibiteur de lymphocytes, lequel est une molécule de type PD-I et lequel est exprimé dans des lymphocytes T. L'invention concerne également la découverte de la capacité de zB7R1 à se lier avec CD155. L'invention concerne également des procédés et des compositions pour moduler des interférences et signalisations négatives à médiation par zB7R1 avec l'interaction de son contre-récepteur dans des buts thérapeutiques, diagnostiques et de recherche.
Bilsborough Janine
Brandt Cameron
Chadwick Eric M.
Gao Zeren
Howard Edward D.
Osler Hoskin & Harcourt Llp
Zymogenetics Inc.
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