C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) C07K 14/47 (2006.01) C07K 14/535 (2006.01) C07K 14/71 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) C12N 9/16 (2006.01) C12N 15/12 (2006.01) C12N 15/27 (2006.01)
Patent
CA 2241373
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by contact with a polypeptide complex constructed by joining together a dendritic cell-binding protein and a polypeptide antigen. Also disclosed are expression vectors and systems for producing the polypeptide complexes.
La présente invention concerne des compositions thérapeutiques et des procédés d'induction de réponses cytotoxiques par les lymphocytes T, in vitro et in vivo. Ces compositions thérapeutiques sont constituées de cellules d'apport d'antigènes rendues actives par contact avec un complexe polypeptide construit par assemblage d'une protéine de liaison cellulaire dendritique avec un antigène polypeptide. L'invention concerne également des vecteurs d'expression et des systèmes de production de complexes polypeptides.
Laus Reiner
Ruegg Curtis Landon
Wu Hongyu
Dendreon Corporation
Gowling Lafleur Henderson Llp
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