C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 15/18 (2006.01) C12P 1/00 (2006.01)
Patent
CA 2412211
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
L'invention porte sur des compositions et procédés stimulant ou inhibant l'angiogenèse et la cardiovascularisation chez les mammifères dont l'homme. Il s'agit de compositions pharmaceutiques à base de polypeptides ou de leurs antagonistes identifiés comme convenant pour l'une ou plusieurs de ces utilisations. Les troubles susceptibles d'être diagnostiqués, prévenus ou traités par lesdites compositions comportent des traumatismes tels que des blessures, divers cancers, et des atteintes aux vaisseaux dont l'athérosclérose et l'hypertrophie cardiaque. L'invention porte également sur de nouveaux polypeptides et sur des molécules d'acides nucléiques codant pour eux. L'invention porte en outre sur des vecteurs et cellules hôtes comportant lesdites séquences d'acides nucléiques, sur des molécules de polypeptide chimères comprenant les polypeptides de l'invention fusionnés avec des séquences de polypeptides hétérologues, et des anticorps se fixant aux polypeptides de l'invention. L'invention porte par ailleurs sur les procédés d'obtention des polypeptides de l'invention.
Baker Kevin P.
Ferrara Napoleone
Gerber Hanspeter
Gerritsen Mary E.
Goddard Audrey
Dennison Associates
Genetech Inc.
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