C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C07K 19/00 (2006.01) C12N 5/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2437564
Compositions and methods for the therapy and diagnosis of cancer, particularly breastcancer, are disclosed. Illustrative compositions comprise one or more breasttumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breastcancer.
L'invention concerne des compositions et des méthodes de thérapie et de diagnostic du cancer, en particulier du cancer du sein. Les compositions de l'invention comprennent un ou plusieurs polypeptides de tumeurs du sein, des parties immunogènes de ceux-ci, des polynucléotides codant pour ces polypeptides, une cellule présentatrice de l'antigène exprimant ces polypeptides, et des lymphocytes T spécifiques aux cellules exprimant ces polypeptides. Les compositions de l'invention sont utilisées, par exemple, dans le diagnostic, la prévention et/ou le traitement de maladies, en particulier le cancer du sein.
Bennington Angela Ann
Day Craig H.
Dillon Davin C.
Fanger Gary R.
Harlocker Susan L.
Borden Ladner Gervais Llp
Corixa Corporation
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